A SIMPLE KEY FOR CHRYSIN-7-O-GLUCURONIDE UNVEILED

Chemotherapy was potentiated by E7449 and one agent had important antitumor activity in BRCA-deficient xenografts. Additionally, E7449 inhibited Wnt/β-catenin signaling in colon most cancers mobile strains, very likely via TNKS inhibition. In line with this likelihood, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and